Integrating Understanding of Epidemiology and Genomics in B-cell Non-Hodgkin Lymphoma as a Pathway to Novel Management Strategies

March 2016 (Discovery Medicine)

Systematic Review

We explore the impact of normal B-cell biology engineered for recognizing a wide variety of antigens on the development of specific lymphoma subtypes, review lymphoma genetics, and examine the epidemiology of B-cell NHLs including recent investigations of risk factors for particular lymphoma subtypes based on large pooled analyses. Burkitt lymphoma, an aggressive form of B-cell NHL involving translocation of the MYC gene and an immunoglobulin gene has been associated with a history of eczema, hepatitis C, and occupation as a cleaner.

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