Guidelines for laboratory testing and result reporting, viral hepatitis serolgy training, signal-to-cut-off ratiois for commercially available assays – – CDC has recommended that a person be considered to have serologic evidence of HCV infection only after an anti-HCV screening-test-positive result has been verified by a more specific serologic test or a nucleic acid test (NAT). This more specific, supplemental testing is necessary, particularly in populations with a lower prevalence of disease, to identify and exclude false positive screening test results. However, currently, the majority of laboratories report positive anti-HCV results based on a positive screening assay alone.
CDC: Guidelines for Laboratory Testing of Hepatitis C
